This brief publication by the Bureau of Justice Assistance and the Office for Victims of Crime provides facts and statistics about the impact of the opioid epidemic on children and adolescents, addressing risks in infancy/preschool; school-aged children; and adolescence. It covers signs of opioid withdrawal following birth; risks to baby due to opioid misuse during pregnancy; consequences of impaired parenting and attachment; extended separation of child from parents; impaired brain development due to exposure to toxic stress during brain development; risk factors for teen drug use; and impact of opioid substance abuse on teens.