The Second Annual National Conference on Science and the Law: Summary of Proceedings summarizes the October 10–14, 2000, conference presentations and discussions. This annual conference brings together members of the scientific, legal, and academic communities to examine and promote an understanding of science among legal professionals and to promote an understanding of the legal system among scientists. Conference speakers explored emerging areas and changing standards of admissibility; concerns surrounding risk assessment and predictions of dangerousness; expert testimony and the role of the judge, jurors, and attorneys; DNA evidence as it is used now and how it may be used in the future; and changes in the treatment of evidence admitted to the court, illustrated through discussions of the Clutter murder case of the 1960s.